Inhibition of Murine Leukemia Virus Replication by Poly(vinyluracil) and Poly(vinyladenine)
- 1 April 1973
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 70 (4) , 1204-1208
- https://doi.org/10.1073/pnas.70.4.1204
Abstract
Poly(1-vinyluracil) and poly(9-vinyladenine), as well as the corresponding polynucleotides poly(uridylate) and poly(adenylate), inhibit acute murine leukemia virus infection in mouse-embryo cells, but they do not significantly inhibit the replication of Sindbis and vesicular stomatitis viruses. The polymers were most effective as inhibitors when added during an early stage of virus replication. Effects of vinyl polymers on the RNA-dependent DNA polymerase from the virions of murine leukemia virus were also observed.Keywords
This publication has 22 references indexed in Scilit:
- Inhibition of cell-free protein synthesis by poly(9-vinyladenine), poly(1-vinyluracil), and the corresponding vinyl copolymerBiochemistry, 1972
- Adenylic Acid-rich Sequence in RNAs of Rous Sarcoma Virus and Rauscher Mouse Leukaemia VirusNature, 1972
- Vinyl analogs of polynucleotidesBiochemistry, 1971
- Mechanism of Cell Transformation by RNA Tumor VirusesAnnual Review of Microbiology, 1971
- VIRAL GENETIC SYSTEMS*†Transactions of the New York Academy of Sciences, 1971
- Streptovaricins inhibit RNA Dependent DNA Polymerase Present in an Oncogenic RNA VirusNature, 1971
- Plaque assay techniques for murine leukemia virusesVirology, 1970
- Preparation and properties of poly‐9‐vinyladenineBiopolymers, 1970
- Poly(1-vinyluracil): The preparation and interactions with adenosine derivativesBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1970
- Counting actively metabolizing tissue cultured cellsExperimental Cell Research, 1957