Sequence and function of the two P domain potassium channels: implications of an emerging superfamily
Open Access
- 2 December 1997
- journal article
- review article
- Published by Springer Nature in Journal of Molecular Medicine
- Vol. 76 (1) , 13-20
- https://doi.org/10.1007/s001090050186
Abstract
A new superfamily of K+ channels has emerged in the past 2 years. Notable for possessing two pore-forming P domains in each subunit, members of the superfamily have been recognized through phylogeny from micro-organisms to humans. Four subfamilies of two P domain channels have been isolated thus far; among these are the first cloned examples of outward rectifier and open rectifier (or leak) K+ channels. The two P domain K+ channels offer a new perspective from which to glimpse the molecular basis for function and dysfunction of K+-selective ion channels.Keywords
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