Immunologic Aspects of Pernicious Anemia

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Abstract
THERE were two facts that suggested that immunologic factors may be of importance in the study of Addisonian (pernicious) anemia. In the first place, this condition has a high incidence in patients with thyroid disease,1 in which autoimmune phenomena are a frequent occurrence.2 Secondly, the histology of the gastric mucosa in pernicious anemia is characterized by atrophy of the specialized cells of the body of the stomach, and this is accompanied by a variable but often marked degree of lymphocytic infiltration.Antibody to Gastric Parietal-Cell CytoplasmBy the method of complement fixation, the serum of 75 per cent of patients . . .