Studies of Hepatic Excretory Function
- 19 August 1965
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 273 (8) , 420-423
- https://doi.org/10.1056/nejm196508192730804
Abstract
AFTER intravenous injection bromsulfalein is bound to albumin and transferred primarily into the liver.1 , 2 The hepatic metabolism of the dye involves uptake and storage,1 , 2 intracellular formation of a glutathione conjugate3 4 5 and subsequent excretion of free and conjugated dye into the bile.4 , 6 The storage in parenchymal liver cells is directly proportional to the plasma concentration, whereas the transfer from the liver cell into the bile appears to be limited by a transfer maximum.2 , 7 A method for the simultaneous estimation of hepatic bromsulfalein storage and excretion has been presented by Wheeler et al.7 Values for the relative hepatic storage, expressed as milligrams . . .Keywords
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