“Original Antigenic Sin” Phenomenon in Experimental Flavivirus Infections of Guinea Pigs: Studies by Enzyme‐Linked Immunosorbent Assay

Publisher Website
Google Scholar
Abstract
Guinea pigs were sequentially infected with 2 closely related flaviviruses (Japanese encephalitis and West Nile viruses); their antibody responses were studied by enzyme-linked immunosorbent assay (ELISA) and hemagglutination-inhibition (HI). The results by ELISA always showed original antigenic sin responses: antibody activity of sera after the 2nd infection was higher to the 1st infecting virus than to the 2nd infecting virus. The results obtained by HI were variable.