Anti-Inflammatory Effects of Synthetic Retinoids May Be Related to Their Immunomodulatory Action

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Abstract
The effects of retinoids have been studied in a model of delayed-type hypersensitivity using the T-cell-dependent antigen, methylated bovine serum albumin to elicit inflammation in the hind paws of mice. A number of synthetic retinoids, including etretinate and arotinoids, showed a marked anti-inflammatory action in this model. Using differential dosing schedules, the anti-inflammatory effect of retinoids was clearly distinguished from conventional cyclooxygenase inhibitors. By screening a number of synthetic retinoids, structure-activity relationships for this effect can be deduced.

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