Global signatures of protein and mRNA expression levels
Top Cited Papers
- 1 October 2009
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Molecular BioSystems
- Vol. 5 (12) , 1512-1526
- https://doi.org/10.1039/b908315d
Abstract
Cellular states are determined by differential expression of the cell’s proteins. The relationship between protein and mRNA expression levels informs about the combined outcomes of translation and protein degradation which are, in addition to transcription and mRNA stability, essential contributors to gene expression regulation. This review summarizes the state of knowledge about large-scale measurements of absolute protein and mRNA expression levels, and the degree of correlation between the two parameters. We summarize the information that can be derived from comparison of protein and mRNA expression levels and discuss how corresponding sequence characteristics suggest modes of regulation.Keywords
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