Chronic Bullous Disease of Childhood and Ulcerative Colitis

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Abstract
A 12‐year‐old girl with ulcerative colitis (UC) treated by colectomy with rectal stump preservation, salazopyrin, and systemic steroids developed persistent mouth ulcers, cutaneous target like lesions, papulopustules, and builae. The clinical, histologic, and immunopatriologic features were typical of chronic bullous disease of childhood (CBDC). Although resistant to combined Immunosuppressive therapy with low‐dose prednisolone, cyclosporin, and thalldomide, striking remission of the mucocutaneous symptoms resulted with surgital resection of the diseased rectal stump. An etiologic association between CBDC and UC Is postulated.