The metabolic relation between hypoxanthine and uric acid in man following maximal short‐distance running

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Abstract
Hellstn Westing, Y., Ekblom, B. & Sjödin, R. 1989. The metabolic relation between hypoxanthine and uric acid in man following masimal short‐distance running. Acta Physiol Scand 1–37, 341–345. Received 10 March 1989, accepted 24 June 1989. ISSN 0001–0772. Department of Physiology III, Karolinska Institute, and Swedish Defence Research Establishment, Stockholm, Sweden.This study was performed to asscss the metabolic relation between hypoxanthine and uric acid following short‐distance maximal running. Eleven trained males, mean age 22 years (16–31), were instructed to run 800 m in the shortest time possible. Bood samples were collected before warm‐up, before the run, immediately after the run and periodically up to 24 h following the run. Blood lactate was determined after warm‐up, and at 5, 10, and 30 min following the run. Mean Vo2 mas for the subjects was 65.8 (4.7) (SD) ml kg‐1 min‐1 and mean oxygen demand for the running was 118 (8)%, of Vo2 may. Plasma hl‐poxanthine levels rose from 3.3 (1.4) to a peak of 48.2 (19.0)μmol l‐1 at to min following the run and at 180 min had almost returned to pre‐tun levels Plasma uric acid levels rose from a pre‐run value of 267 (34) to a peak value of 131 (87) μmol l‐1 at 45 min following the run. Uric acid concentrations had not returned to normal at 10 h following the run. The hlood lactate level peaked at j min with 13.7 (2.0) mmol l‐1. The results obtained in this study indicate a metabolic relationship between the formation of hypoxanthine and the formation of uric acid. The data also indicate that xanthine osidase is active following short‐distance intensive running.