LIS1—no more no less
- 1 January 2002
- journal article
- review article
- Published by Springer Nature in Molecular Psychiatry
- Vol. 7 (1) , 12-16
- https://doi.org/10.1038/sj.mp.4000975
Abstract
LIS1 is one of the genes that has a principle role in brain development since hemizygote mutations in LIS1 result in a severe brain malformation known as lissencephaly ('smooth brain'). LIS1 is a WD repeat protein and is known to be involved in several protein complexes that are likely to play a functional role in brain development. We discuss here the brain developmental phenotype observed in mice heterozygote for an N-terminal truncated LIS1 protein in view of known LIS1 protein interactions.Keywords
This publication has 68 references indexed in Scilit:
- NUDF, a Fungal Homolog of the Human LIS1 Protein, Functions as a Dimer in VivoPublished by Elsevier ,2001
- Microtubule-Based Transport Systems in Neurons: The Roles of Kinesins and DyneinsAnnual Review of Neuroscience, 2000
- Point Mutations and an Intragenic Deletion in LIS1, the Lissencephaly Causative Gene in Isolated Lissencephaly Sequence and Miller-Dieker SyndromeHuman Molecular Genetics, 1997
- Synaptic Activity and the Construction of Cortical CircuitsScience, 1996
- Folding of Proteins with WD-Repeats: Comparison of Six Members of the WD-Repeat Superfamily to the G Protein β SubunitBiochemistry, 1996
- Platelet-activating factor produces neuronal growth cone collapseNeuroReport, 1995
- The ancient regulatory-protein family of WD-repeat proteinsNature, 1994
- A characterization of Hardy-Orlicz spaces on planar domainsProceedings of the American Mathematical Society, 1993
- Requirement for subplate neurons in the formation of thalamocortical connectionsNature, 1990
- Neuroregulatory and Neuropathological Actions of the Ether-Phospholipid Platelet-Activating FactorScience, 1988