From Bedside to Bench to Bedside to Clinical Practice: An Odyssey with Irinotecan
Open Access
- 15 March 2006
- journal article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 12 (6) , 1658-1660
- https://doi.org/10.1158/1078-0432.ccr-06-0159
Abstract
No abstract availableThis publication has 15 references indexed in Scilit:
- Modulation of irinotecan with cyclosporine: a phase II trial in advanced colorectal cancerCancer Chemotherapy and Pharmacology, 2005
- Managing Familial Risk in Genetic TestingGenetic Testing, 2004
- UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer*1Clinical Pharmacology & Therapeutics, 2004
- Genetic Variants in the UDP-glucuronosyltransferase 1A1 Gene Predict the Risk of Severe Neutropenia of IrinotecanJournal of Clinical Oncology, 2004
- UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicityThe Pharmacogenomics Journal, 2002
- Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphismClinical Pharmacology & Therapeutics, 1999
- Racial variability in the UDP-glucuronosyltransferase 1 ( UGT1A1 ) promoter: A balanced polymorphism for regulation of bilirubin metabolism?Proceedings of the National Academy of Sciences, 1998
- Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes.Journal of Clinical Investigation, 1998
- Genetic variation in bilirubin UDP-glucuronosyltransferase gene promoter and Gilbert's syndromeThe Lancet, 1996
- The Genetic Basis of the Reduced Expression of Bilirubin UDP-Glucuronosyltransferase 1 in Gilbert's SyndromeNew England Journal of Medicine, 1995