4′C-Ethynyl-thymidine acts as a chain terminator during DNA-synthesis catalyzed by HIV-1 reverse transcriptase
- 15 February 2005
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 15 (4) , 869-871
- https://doi.org/10.1016/j.bmcl.2004.12.072
Abstract
No abstract availableKeywords
This publication has 16 references indexed in Scilit:
- A 4‘-C-Ethynyl-2‘,3‘-Dideoxynucleoside Analogue Highlights the Role of the 3‘-OH in Anti-HIV Active 4‘-C-Ethynyl-2‘-deoxy NucleosidesJournal of Medicinal Chemistry, 2004
- Antiviral drugs in current clinical usePublished by Elsevier ,2004
- Increased G→A Transition Frequencies Displayed by Primer Grip Mutants of Human Immunodeficiency Virus Type 1 Reverse TranscriptaseJournal of Virology, 2004
- Exploring the Effects of Active Site Constraints on HIV-1 Reverse Transcriptase DNA Polymerase FidelityPublished by Elsevier ,2002
- Implications of Active Site Constraints on Varied DNA Polymerase SelectivityJournal of the American Chemical Society, 2002
- Nucleosides and Nucleotides. 185. Synthesis and Biological Activities of 4‘α-C-Branched-Chain Sugar Pyrimidine NucleosidesJournal of Medicinal Chemistry, 1999
- Nucleosides and nucleotides. 183. Synthesis of 4′ α-branched thymidines as a new type of antiviral agentBioorganic & Medicinal Chemistry Letters, 1999
- Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody fab fragment at 2.8 Å resolutionJournal of Molecular Biology, 1998
- 4‘-Acylated Thymidines: A New Class of DNA Chain Terminators and Photocleavable DNA Building BlocksJournal of the American Chemical Society, 1997
- Selective action of 4'-azidothymidine triphosphate on reverse transcriptase of human immunodeficiency virus type 1 and human DNA polymerases .alpha. and .beta.Biochemistry, 1993