Design and synthesis of a β‐strand inducer Application to ICAM‐1/LFA‐1 mediated cellular adhesion
- 22 January 1996
- journal article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 47 (1-2) , 2-8
- https://doi.org/10.1111/j.1399-3011.1996.tb00803.x
Abstract
The binding of lymphocyte function associated antigen (LFA-1) to intercellular adhesion molecule (ICAM-1) is responsible for several types of cellular adhesion. Amino-acid substitution mutants of ICAM-1 have established the importance of several sequences in this protein. We selected the binding region of Glu34 for further study. One published model of domain 1 placed Glu34 near the end of a beta-strand. We designed and synthesized three tripeptide derivatives centered on the Glu34 sequence and attached a platform which, through hydrogen bonds, induces a rigid beta-strand conformation. Variable temperature NMR methods coupled with NOESY 2D NMR data enabled determination of the solution conformation of these compounds.Keywords
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