Autoradiographic localization of binding sites for oxytocin and vasopressin in the rat kidney
- 1 May 1987
- journal article
- research article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 113 (2) , 179-+
- https://doi.org/10.1677/joe.0.1130179
Abstract
The distribution of [3H]vasopressin- and [3H]oxytocin-binding sites was examined, using an autoradiographical technique, in the kidney of Long–Evans and Brattleboro rats. Two types of binding sites with affinities in the nanomolar range were detected: one, located on glomeruli, bound both vasopressin and oxytocin; the other, on collecting ducts, bound vasopressin selectively. In the presence of 10 μmol oxytocin/1, [3H]vasopressin labelling was abolished in glomeruli, but only reduced in collecting ducts; [3H]oxytocin labelling was completely abolished by 10 μmol vasopressin/1. These observations are discussed in relation to known effects of neurohypophysial hormones on renal physiology. J. Endocr. (1987) 113, 179–182This publication has 0 references indexed in Scilit: