DYE-SENSITIZED PHOTOINACTIVATION OF YEAST IN RELATION TO THE X-RAY OXYGEN EFFECT

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Abstract
Under anaerobic conditions, X-rays cuase latent, nonlethal lesions which enhance the sensitivity of surviving cells to subsequent inactivation by visible light in the presence of the nucleic-acid fluorochrome, acridine orange. No such enhanced sensitization occurs if the X-rays are delivered under aeorbic conditions, or if the order of the radiations is reversed, or when UV light is substituted for the dye-visible light treatment. Thus, conditions which appear to protect cells from the effects of X-rays (e.g. anoxia), may, at the same time, serve to promote the formation of X-ray-induced lesions that sensitize them in other ways.