REGULATION OF INSULIN GENE-EXPRESSION BY DEXAMETHASONE, CA-2+ AND A PHORBOL ESTER

  • 1 January 1988
    • journal article
    • research article
    • Vol. 47  (4-5) , 299-303
Abstract
The transcription of the insulin genes in rat pancreatic islets was determined in response dexamethasone, cholera toxin and Ca2+. Furthermore, the contents of islet insulin mRNA after culture with the phorbol ester 4.beta.-phorbol 12-myristate 13-acetate (TPA) were assayed by dot-blot analysis. Dexamethasone and cholera toxin stimulated the rates of insulin gene transcription, whereas the withdrawal of Ca2+ and addition of TPA exerted no effects on insulin gene in response to nutrient secretagogues, whereas Ca2+ and activation of protein kinase C do not serve such a function.

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