An Analysis of the Drugs Acting on Cerebral Energy Metabolism
Open Access
- 1 January 1975
- journal article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 25 (3) , 251-261
- https://doi.org/10.1254/jjp.25.251
Abstract
The behaviour of (a) the redox potential of the lactate/pyruvate system and the changes of the redox potential of the lactate/pyruvate system across the brain; (b) the energy charge potential of the adenylate pool, was studied in the brain of curarized beagle dogs. The influence of certain drugs (amobarbital, nicergoline, theophylline, papaverine, bamethan, dipyridamole, bemegride) on these parameters was evaluated under control conditions, during hypoxemia and during post-hypoxiemic recovery. On the whole, the action on energetic metabolism appears to be unrelated to the action believed to be exerted by drugs on cerebral vessels.Keywords
This publication has 14 references indexed in Scilit:
- Effects on Cerebral Energy State of Arterial Hypotension in Rats with Porta-Caval AnastomosisActa Physiologica Scandinavica, 1974
- Estimation of Changes Induced by Drugs in Cerebral Energy-Coupling Processes In Situ in the DogJournal of Pharmaceutical Sciences, 1973
- Effect of Lysergide and Nimergoline on Glucose Metabolism Investigated on the Dog Brain Isolated In SituJournal of Pharmaceutical Sciences, 1972
- The Influence of Arterial Hypoxemia upon Labile Phosphates and upon Extracellular and Intracellular Lactate and Pyruvate Concentrations in the Rat BrainScandinavian Journal of Clinical and Laboratory Investigation, 1971
- The Effect of Anesthetics upon Labile Phosphates and upon Extra- and Intracellular Lactate, Pyruvate and Bicarbonate Concentrations in the Rat BrainActa Physiologica Scandinavica, 1970
- The Effect of Hypovolemic Hypotension on Extra- and Intracellular Acid-Base Parameters and Energy Metabolites in the Rat BrainActa Physiologica Scandinavica, 1970
- Monitoring Cerebral Blood Flow and Oxygen, Glucose, Lactate and Ammonia MetabolismCirculation Research, 1967
- Regional Blood Flow in the Cerebral Cortex, Measured Simultaneously by Heat and Inert Gas ClearanceActa Physiologica Scandinavica, 1966
- Electromagnetic Measurement of Internal Jugular Venous Flow in the MonkeyJournal of Neurosurgery, 1964
- CORRELATION OF CONCENTRATIONS OF ETHER IN ARTERIAL BLOOD WITH ELECTRO–ENCEPHALOGRAPHIC PATTERNS OCCURRING DURING ETHER–OXYGEN AND DURING NITROUS OXIDE, OXYGEN AND ETHER ANESTHESIA OF HUMAN SURGICAL PATIENTSAnesthesiology, 1952