Cobalt(II) Chloride-Catalyzed Chemoselective Sodium Borohydride Reduction of Azides in Water

31 December 2000

journal article
research article
Published by Georg Thieme Verlag KG in Synthesis

Vol. 2000 (05) , 646-650
https://doi.org/10.1055/s-2000-6389

Abstract

Reduction of azides to amines and amides was carried out with NaBH₄/CoCl₂ · 6 H₂O in sole water at 25 °C under catalytic heterogeneous conditions. A broad spectrum of azides was reduced in a short time, chemoselectively in high yield and purity.

Keywords

AZIDE
REDUCTION
COBALT(II) CHLORIDE
SODIUM BOROHYDRIDE

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