Toxicity of Drugs in Premature Infants
- 24 December 1959
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 261 (26) , 1343-1344
- https://doi.org/10.1056/nejm195912242612611
Abstract
IN a panel discussion in Washington in November, 1955, Andersen1 reported on a study of the prophylactic use of antibiotics in premature infants, comparing 10 mg. of oxytetracycline per kilogram of body weight per day with 100,000 units of penicillin combined with 150 mg. per kilogram per day of the diethanolamine salt of sulfisoxazole, all given parenterally for the first five days of life. There were 27 deaths among 97 infants receiving oxytetracycline, and in only 1 was kernicterus found at autopsy, whereas 60 of 94 treated with penicillin and sulfisoxazole died and 20 of those examined at autopsy had . . .Keywords
This publication has 1 reference indexed in Scilit:
- Inability of newborn mice and guinea pigs to metabolize drugsBiochemical Pharmacology, 1959