The role of the pyrimidine 4-amino-group in thiamine
- 1 January 1966
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society C: Organic
- Vol. 7 (7) , 649-653
- https://doi.org/10.1039/j39660000649
Abstract
A number of analogues of thiamine, bearing 4- or 4,6-substituents, have been synthesised in order to establish whether there is a relation between their ability to catalyse the decarboxylation of pyruvic acid and the electron-withdrawing inductive effect of their substituted 5-pyrimidylmethyl groups as exemplified by the pKa of the corresponding substituted 5-pyrimidylmethylamines. It has been established that no such correlation exists and that the 5-pyrimidylmethyl groups are therefore unlikely to be influencing catalytic ability by an inductive effect.This publication has 1 reference indexed in Scilit:
- On the Mechanism of Thiamine Action. IV.1 Evidence from Studies on Model SystemsJournal of the American Chemical Society, 1958