BALB/cfRIII: A New High Mammary-Tumor and High Leukemia Mouse Strain2

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Abstract
A new inbred strain was established from a litter of BALB/c mice foster-nursed by Rill. This strain, named BALB/cfRIII, carried the mammary tumor virus, received through Rill milk, and a leukemia virus. Accordingly, BALB/cfRIII mice showed a high incidence of mammary tumors and lymphatic leukemia. During the first 30 generations of inbreeding, 1292 BALB/cfRIII mice were observed: 463 males, 723 breeding females (573 normally bred and 150 force-bred), and 106 virgin females. The pattern of spontaneous tumorigenesis was as follows: mammary tumors: 18.9% at 571 days of age in virgin females, 75.2% at 324 days in normally bred females, and 85.3% at 237 days in force-bred females; lymphatic leukemia: 43.6% at 380 days in males, 58.5% at 446 days in virgin females, 15.9% at 343 days in normally bred females, and 13.3% at 282 days in force-bred females. Lung tumors (3%) and ovarian tumors were sporadically observed in old mice. Association between mammary tumors and leukemia was rare. Most mammary tumors were pregnancy dependent. These data were compared with those of the strain of origin BALB/c and the milk-donor strain RIII.

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