A Homogeneous Emulsion of Fat, Protein, and Glucose for Intravenous Administration

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Abstract
Two types of fat emulsion have been prepared. One was an emulsion of coconut oil and serum albumin which, on homogenization, yielded a stable prepn. well tolerated intravenously. The second was derived from glucose, protein, and fat. The basic proportions which were mixed were: 1 1. of 6% infusion gelatin (Knox P-20), 1 1. of protein hydrolysate, 5% amino acid soln., 200 ml. of 50% glucose soln., and 100 g. of pure refined, edible coconut oil. The mixture was agitated, homogenized, put in sterile vacuum bottles, and refrigerated. Complete stability was seen after 2 mos.'' storage. The concs. of fat, protein, and glucose were 5% each and averaged 800 cals./l. Intraven. injn. into dogs and man produced no serious untoward reactions. In autopsied dogs, there was no evidence of fatty degenerative changes in the liver, lung, brain, and other organs.# One malnourished patient received a total of 5,500 ml. of the emulsion (200 g. of fat) intravenously for 8 days. The emulsion caused no thrombosclerotic changes in the recipient vein and was non-irritating when infiltrated into tissue. Vit. B and methyl donators were given to ensure utilization of fat. Penicillin could be added for intraven. admn.

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