Mineral apposition rates of human cancellous bone at the interface of porous coated implants

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Abstract
Human cancellous bone ingrowth studies were conducted on 19 consenting bilateral total knee arthroplasty (TKA) patients. Titanium porous coated cylinders were implanted into the medial femoral condyle of the contralateral knee during the first of two TKAs. Retrieval was performed at the time of the second TKA (6–131 weeks later), and fluorochrome analysis was conducted. Mean mineral apposition rates (MAR) at the interface measured 1.0 μm/day, whereas 4 mm away, the peripheral bone had a mean MAR of 0.8 μm/day. This represented a 25% acceleration in the interface bone remodeling rate when compared with the periphery (P < .05). This study showed the bone advanced appositionally at the interface at a rate of ≈ 1 μm/day. Analysis showed that when bone was over 50 μm from the porous coating, bone ingrowth did not occur. These results emphasize the need for surgical precision and careful postoperative management to achieve bone ingrowth. © 1994 John Wiley & Sons, Inc.