A One-Pot Transformation of Ketones Into N-(Meth)Acryloyl-2-Amino Acids
- 1 May 1987
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 17 (7) , 843-862
- https://doi.org/10.1080/00397918708063942
Abstract
A synthetic sequence for the preparation of N-(meth)acryloyl-2-amino acids is outlined which involves transformation of a ketone successively into an aminonitrile and a (meth)acrylamidonitrile, followed by selective hydrolysis of the nitrile function. All reactions are performed in aqueous media, in one reaction vessel, and in a stepwise manner without isolation of any intermediate products.Keywords
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