Response of Children to Neisseria meningitidis Polysaccharide Vaccines

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Abstract
Children aged two to six years were inoculated with various amounts of group C Neisseria meningitidis polysaccharide vaccine. Doses of 5, 25, and 50 µg were less satisfactory in eliciting antibody than larger doses of 100 or 250 µg. Antibody response was directly related to age. Children in three of the vaccinated groups were inoculated again eight months later with 50 µg of both group A and group C vaccines. Booster responses occurred in all groups, and those who received the highest doses originally still had the greatest amount of antibody to group C N. meningitidis. All responded to group A vaccine. The hemagglutination method did not offer sufficient sensitivity in detection of antibody, but the radioimmunoassay procedure was satisfactory. However, even with this sensitive technique, the response in children was of lower magnitude than that in adults given smaller doses of vaccine.

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