Acute hemodynamic effects of alpha human atrial natriuretic polypeptide in patients with congestive heart failure.
Open Access
- 1 January 1988
- journal article
- research article
- Published by International Heart Journal (Japanese Heart Journal) in Japanese Heart Journal
- Vol. 29 (2) , 143-149
- https://doi.org/10.1536/ihj.29.143
Abstract
Acute hemodynamic and humoral effects of synthesized alpha human atrial natriuretic polypeptide (α-hANP, 0.025μg/kg/min for 40 min) on 6 patients with severe congestive heart failure were assessed. Plasma α-hANP concentration was high in patients and increased further (from 463±360 to 1, 282±670pg/ml, mean±SD, p+ excretion rate (87±89 to 257±211mEq/min/m2) were statistically insignificant. A significant reduction was induced in mean aortic pressure (99±25 to 96±26mmHg, p<0.05), mean right atrial pressure (11±9 to 7±8mmHg, p<0.01), mean pulmonary arterial pressure (39±13 to 33±12mmHg, p<0.05) and mean pulmonary capillary wedge pressure (27±8 to 20±7mmHg, p<0.01). Heart rate, cardiac index, systemic vascular resistance and pulmonary vascular resistance were not altered. In conclusion, α-hANP induced decreases in left ventricular filling pressure and rightside heart pressure which were attributed to venodilatation rather than natriuretis in patients with congestive heart failure. Preserved cardiac output with decreased preload suggested that α-hANP improved cardiac function.Keywords
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