Chemically Bonded Cyclodextrin Silica Stationary Phases for Liquid Chromatographic Separation of Some Disubstituted Benzene Derivatives

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Abstract
Chemically bonded β-cyclodextrin stationary phases for high-performance liquid chromatography are prepared by immobilizing derivatives of β-cyclodextrin with the moiety containing the s-triazine ring onto silica gels that are modified with different amino types of silane coupling agents. The retention behavior of some disubstituted benzene derivatives is examined. Results show that effective and efficient separation is achieved. Comparative studies of the retention behavior of disubstituted benzene derivatives are made for β-cyclodextrin bonded phases with and without the moiety of the s-triazine ring. The results of the present investigation indicate that formation of the inclusion complex plays a dominant role in the separation mechanism. However, selectivity can be significantly enhanced by the interaction between the s-triazine ring of the bonded phase and the eluted disubstituted benzene derivatives.

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