The Preparation of a Spinach Tissue-Based Carbon Paste Microelectrode and Its Performance in Pharmacokinetic Experiments In Vivo

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Abstract
A novel spinach tissue-based carbon paste microelectrode was prepared for the determination of dopamine (DA) both in ritro and in vivo. The electrode has shown higher sensitivity, higher selectivity and shorter response times than the unmodified carbon paste eletrode, the banana tissue-based carbon paste electrode and the spinach electrode used in potentiometry. The linear range is 1.7×10−6-1.6×10−4mol/L, and the detection limit is 7.1×10−7mol/L. In the pharmacokinetic experiments, the electrode is used to determine dopamine in vivo. The results indicate that the electrode is potentially useful for studies of dopamine in vivo.