DETOXICATION OF PHOSPHONOTHIOATES AND PHOSPHONOFLUORIDATES IN THE RAT

1 January 1978

journal article
research article

Vol. 37 (8) , 1261-1265

Abstract

O-Isopropylmethyl phosphonofluoridate and O-ethyl-S-(2-dimethylaminoethyl) methylphosphonothioate were i.m. administered in doses of 2 .times. LD50 to female rats and the blood acetylcholinesterase (AChE, EC 3.1.1.7) was continuously monitored using the automatic colorimeter Auto Analyzer. This activity decreased after the injection of the 2 organophosphates studied. If the blood flow in the leg muscles was stopped by compression and reopened by relaxation at different intervals, acetylcholinesterase activity was either unaffected (detoxication present) or decreased (detoxication absent). Phosphonofluoridate was detoxified but phosphonothioate was not in the rat.

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