Effect of Carbon Tetrachloride Upon Glucuronide Formation by Guinea Pig Liver.
- 1 April 1960
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 103 (4) , 819-822
- https://doi.org/10.3181/00379727-103-25682
Abstract
Guinea pigs were injected with CCl4 intravenously (0.1 ml/kg). Glucuronyl transferase activity was then measured in whole homogenates and in isolated microsomes using p-nitrophenol as substrate. Reduction in enzyme activity was apparent in 24 hours but demonstrable as early as 2 hours after injection. Glucuronyl transferase activity of isolated microsomes was not diminished. The reduction in hepatic glucuronide conjugation induced by CCl4 was due to a quantitative change in microsomal activity rather than to a qualitative one.Keywords
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