The inhibitory effect of reserpine on the active sodium transport across the frog bladder

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Abstract
1. The effects of reserpine and harman derivatives on the sodium transport across the frog bladder were examined using a short-circuit current method. The effects of harman derivatives on the Na,K-ATPase activity of the frog kidney were also investigated. 2. Reserpine and harman derivatives inhibited active sodium transport of the frog bladder and their inhibitory effect decreased as reserpine>harmine >harmaline=harman>harmalol. 3. Harman derivatives inhibited Na,K-ATPase activity of the frog kidney. 4. These results suggest that reserpine and harman derivatives inhibit active sodium transport by suppressing the Na,K-ATPase activity of the frog bladder.