Some Effects of Aureomycin and Penicillin on Thiamine and Riboflavin Metabolism in Growing Rats.

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Abstract
In a study of the effects of aureomycin and penicillin on thiamine and riboflavin metabolism in growing rats receiving adequate and restricted intakes of the 2 vitamins, data were obtained which show that supplementation with the antibiotics resulted in increased food intake when the intake of either or both of the 2 vitamins was inadequate, and also improved food utilization, particularly when thiamine intake was sub-optimum. The data also show that the amount of thiamine accounted for increased with antibiotic feeding but never equaled the amount of vitamin ingested. Thiamine absorption was improved in the presence of dietary antibiotics, particularly penicillin, as indicated by lower thiamine concentration in ceca and feces and by higher thiamine concentration in liver and urine. The data show increased riboflavin absorption in the presence of the antibiotics as indicated by lower concentration of the vitamin in ceca and feces and higher concentration in the liver. The data do not exclude the possibility of riboflavin synthesis in the animal body but indicate that the antibiotics exerted no influence in this respect.