Reduced Acute Toxicity of Antigens in Saline-in-Mineral-Oil Emulsion
Open Access
- 1 July 1945
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 51 (1) , 39-43
- https://doi.org/10.4049/jimmunol.51.1.39
Abstract
Summary: The acute lethal toxicity of Shiga neurotoxin, tetanus toxin, botulinus toxin, ricin and Flexner paradysentery somatic antigen for mice, is materially reduced by the administration of these agents in a saline-in-mineral-oil emulsion. The possible significance of this method of preparing vaccine for immunization procedures is discussed.Keywords
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