Intracellular Pools of Thymidine Reduce the Antiviral Action of Acyclovir
- 1 January 1983
- journal article
- research article
- Published by S. Karger AG in Intervirology
- Vol. 20 (1) , 48-51
- https://doi.org/10.1159/000149373
Abstract
Acyclovir inhibits herpes simplex virus (HSV) infections better in human fibroblasts than in green monkey kidney cells. Thymidine and acyclovir compete for the active site of HSV thymidine kinase. Large intracellular pools of thymidine found by high-performance liquid chromatography (HPLC) seemed to be responsible for the reduced activity of acyclovir. Such intracellular thymidine pools could not be measured previously, and the HPLC technique may help in evaluating the expected efficiency of acyclovir in cells and tissues prior to treatment.Keywords
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