Uptake as a Determinant of Methotrexate Response in Mouse Leukemias
- 5 November 1965
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 150 (3697) , 752-754
- https://doi.org/10.1126/science.150.3697.752
Abstract
Methotrexate-promoted survival of mice bearing different transplantable leukemias was compared with uptake of the drug by leukemia cells in vitro. A high degree of correlation (r2 = 0.88) showed that uptake may be a major determinant of the antitumor activity of methotrexate against transplantable mouse leukemias.This publication has 19 references indexed in Scilit:
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