Platelet Activation by Low Density Lipoprotein and High Density Lipoprotein
- 1 July 2006
- journal article
- review article
- Published by S. Karger AG in Pathophysiology of Haemostasis and Thrombosis
- Vol. 35 (3-4) , 270-280
- https://doi.org/10.1159/000093220
Abstract
Cardiovascular disease is the main cause of death and disability in the Western society. Lipoproteins are important in the development of cardiovascular disease since they change the properties of different cells involved in atherosclerosis and thrombosis. The interaction of platelets with lipoproteins has been under intense investigation. Particularly the initiation of platelet signaling pathways by low density lipoprotein (LDL) has been studied thoroughly, since platelets of hypercholesterolemic patients, whose plasma contains elevated LDL levels due to absent or defective LDL receptors, show hyperaggregability in vitro and enhanced activity in vivo. These observations suggest that LDL enhances platelet responsiveness. Several signaling pathways induced by LDL have been revealed in vitro, such as signaling via p38 mitogen-activated protein kinase and p125 focal adhesion kinase. High density lipoprotein (HDL) consists of two subtypes, HDL(2) and HDL(3), which have opposing effects on platelet activation. This review provides a summary of the activation of signaling pathways after platelet-LDL and platelet-HDL interaction, with special emphasis on their role in the development of thrombosis and atherosclerosis.Keywords
This publication has 87 references indexed in Scilit:
- Binding of Low Density Lipoprotein to Platelet Apolipoprotein E Receptor 2′ Results in Phosphorylation of p38MAPKJournal of Biological Chemistry, 2004
- Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) Inhibits Low Density Lipoprotein-induced Signaling in PlateletsJournal of Biological Chemistry, 2003
- Site-specific phosphorylation of platelet focal adhesion kinase by low-density lipoproteinBiochemical Journal, 2003
- Suppression of Endothelial Cell Apoptosis by High Density Lipoproteins (HDL) and HDL-associated LysosphingolipidsJournal of Biological Chemistry, 2001
- High-Density Lipoproteins Protect Endothelial Cells from Tumor Necrosis Factor-α-Induced ApoptosisBiochemical and Biophysical Research Communications, 2000
- Regulatory Effects of HDL on Smooth Muscle Cell Prostacyclin ReleaseArteriosclerosis, Thrombosis, and Vascular Biology, 1999
- HDL3 Activates Phospholipase D in Normal but Not in Glycoprotein IIb/IIIa-Deficient PlateletsBiochemical and Biophysical Research Communications, 1995
- Enhancement of platelet functions by low density lipoproteinsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1992
- High-density lipoprotein inhibits the oxidative modification of low-density lipoproteinBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1990
- Low density lipoprotein binding to human platelets: Role of charge and of specific amino acidsBiochemical and Biophysical Research Communications, 1981