Adrenal Function Tests in Mice Sensitized to Histamine with Hemophilus pertussis Vaccine.

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Abstract
Pertussis -inoculated mice which respond to histamine and other substances in a similar manner to adrenalectomized animals were tested for adrenal function by their ability to maintain their liver glycogen at re-duced atmospheric pressures. An increase in liver glycogen occurred in both fasting uninoculated and fasting pertussis-inoculated mice when exposed to a pressure of half an atmosphere for 24 hrs. Exposure at a pressure of three-eighths of an atmosphere for 24 hrs. killed 17 of 18 pertussis-inoculated mice and only 3 of 18 uninoculated animals.