Multivariate analysis of clinical and biological data in cirrhotic patients: application to prognosis

Publisher Website
Google Scholar
Abstract
One hundred and thirty-one patients underwent clinical and biological investigations with the following determinations performed on the same day; presence or absence of ascites, icterus and/or encepha-lopathy, coagulation study, biochemical determinations including albumin, transferrin and immuno-globulins immunoassays. The principal component analysis of biological data showed two sets of highly representative and inversely correlated data; one included coagulation tests, albumin and transferrin, and the other included immunoglobulin A/transferrin ratio, immunoglobulin A and total bilirubin. Clinical and biological data were computed using discriminant analysis between dead and survivors. Six parameters were then selected (total bilirubin, ence-phalopathy, factor V, AST, antithrombin III and transferrin) giving a correct prognosis in 81.6% (31 /38) of cases in a test sample. Neither ascites nor immuno-globulins were useful for the estimation of the prognosis.

This publication has 28 references indexed in Scilit: