Changes in Semen Quality and Fertility in Response to Endocrine Treatment of Subfertile Men

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Abstract
Subfertile men [786] received hormonal treatment to improve their semen quality and concentration. Most of their semen was characterized as idiopathic oligo- or asthenozoospermia. No cases of hypothalamohypopituitary-hypogonadism were included in this study. Men [117] received human chorionic gonadotropin (hCG); 47% showed improvement in semen quality, mainly in motility and morphology. Ten pregnancies were recorded among 44 couples (23%). Men [37] received human menopausal gonadotropin (hMG) + HCG; a 46% improvement was seen in semen quality, mainly in the motility and concentration and 3 pregnancies were recorded among 20 couples (15%). Men [60] received clomiphene citrate; 47% showed improvement in semen quality, mainly in the concentration and motility. Two pregnancies were recorded among 33 couples (6%). Men [270] received androgen, usually in small doses; 61% had improvement in semen quality, mainly in the motility and morphology, and 24 pregnancies were recorded among 58 couples (41%). Men [262] received pregnant mare serum (PMS; Gestyl) and testosterone; 71% had improvement in semen quality in all the parameters measured especially in motility and vitality, but only 24 pregnancies were recorded among 87 couples (28%). Men [40] received treatment for improvement of potency which included androgen, yohimbine and strychnine; 60% showed improvement in sexual potency, 65% showed a significant improvement in semen quality and 4 pregnancies were recorded among 15 couples (27%). The parameters for improvement of sperm quality were motility, concentration, morphology and vitality. Improvement in semen quality was not necessarily correlated with attainment of pregnancy.