Pyrrolo[1,4]benzodiazepine antibiotics. Biosynthesis of the antitumor antibiotic sibiromycin by Streptosporangium sibiricum
- 18 September 1979
- journal article
- research article
- Published by American Chemical Society (ACS) in Biochemistry
- Vol. 18 (19) , 4225-4229
- https://doi.org/10.1021/bi00586a029
Abstract
The biosynthesis of the antitumor antibiotic sibiromycin by S. sibiricum requires the construction of 4 units: the amino sugar from glucose; the anthranilate ring from DL-tryptophan, probably via kynurenine; the aromatic methyl group from methionine; and the propylidene proline from L-tyrosine with the loss of 2 aromatic C and addition of a C-1 from methionine. Retention of 3H from DL-[5-3H]tryptophan in sibiromycin suggests an NIH shift during hydroxylation of an intermediate.This publication has 0 references indexed in Scilit: