Revisited Conformational Aspects of Pro and Hyp Pyrrolidine Rings In Bicyclic Peptide Systems

Abstract
Pyrrolidine ring conformational aspects in some bicyclic Pro and Hyp derivatives (DKP and Hydantoin) are analyzed from 1H nmr data using a generalised Karplus equation as developed by Haasnoot e.a. (3, 4). Previously published data are corroborated, but those for c/Pro, Hyp/ and c/Pro‐β‐Pro/ have been refined and re‐interpreted.