Immunosuppressive therapy and results of renal transplantation
- 1 April 1992
- journal article
- research article
- Published by Wolters Kluwer Health in Current Opinion in Urology
- Vol. 2 (2) , 141-148
- https://doi.org/10.1097/00042307-199204000-00013
Abstract
Contemporary immunosuppression, which is almost universally cyclosporine A (CsA)-based, has produced progressive improvements in transplantation results. The combination of CsA with other agents like azathioprine, prednisone, anti-lymphocyte/anti-thymocyte globulins (ALG), and anti-CD3 antibody (OKT-3) may provide a smoother post-transplant course, but CsA toxicity remains a potentially important clinical problem. Newer agents like FK-506, RS-61443, rapamycin, deoxyspergualin, and monoclonal antibodies may improve results further with less toxicity.Keywords
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