Non-precipitating antithyroglobulin studied by the Ouchterlony technique.

  • 1 October 1959
    • journal article
    • Vol. 2  (4) , 309-21
Abstract
Non-precipitating antibody reacting with human thyroglobulin has been found in the serum of a patient with Hashimoto's disease. On Ouchterlony plates this antibody causes a clear line to develop in the slightly cloudy agar instead of the usual dense white precipitate: it is capable of blocking the action of certain precipitating Hashimoto sera, whereas other `enhancing' Hashimoto sera enable the non-precipitating serum to take part in precipitate formation. A consideration of this phenomenon suggests that the non-precipitating serum reacts at different sites on the same antigen molecule from the enhancing serum. This reaction provides a mechanism whereby two lines of precipitate may be formed in agar with a single pure antigen.

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