DIASTEREOFACE-DIFFERENTIATING ADDITION OF ORGANOMETALLICS TOWARD CHIRAL α-KETOENAMINES
- 5 December 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 13 (12) , 2055-2058
- https://doi.org/10.1246/cl.1984.2055
Abstract
The diastereoface-differentiating reaction of Grignard reagents or organolithium reagents toward chiral cyclic α-ketoenamines, prepared from the corresponding cycloalkane-1,2-dione and optically active pyrrolidine derivatives, was found to give, after hydrolysis, (R)- or (S)-α-hydroxycycloalkanones, respectively, in high enantiomeric excess.Keywords
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