Association of the 480 bp DAT1 allele with methylphenidate response in a sample of Irish children with ADHD
- 9 June 2003
- journal article
- research article
- Published by Wiley in American Journal Of Medical Genetics Part B-Neuropsychiatric Genetics
- Vol. 121B (1) , 50-54
- https://doi.org/10.1002/ajmg.b.20071
Abstract
Several studies have implicated the dopamine transporter gene (DAT1) as conferring susceptibility to attention deficit hyperactivity disorder (ADHD), in particular, a VNTR situated at the 3′ end of the gene. In addition, the 10‐repeat VNTR allele associated with ADHD has been reported to be associated with an over‐active transporter protein (DAT). Thus children possessing this variant might be particularly responsive to methylphenidate, a drug known to act by blocking DAT. We have examined this hypothesis and now report an association between the 10‐repeat VNTR DAT1 polymorphism and retrospectively rated methylphenidate response in a sample of 119 Irish children with ADHD (χ2 = 7.918, df = 1, P = 0.005). Our findings suggest a role for the 10‐repeat DAT1 risk allele in medication response and may help to predict positive clinical outcome in ADHD.Keywords
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