EFFECTS OF DISTENTION OF THE GALL BLADDER AND BILIARY DUCTS ON THE MOVEMENTS OF THE STOMACH AND THE INTESTINE IN THE DOG

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Abstract
The reflex responses of the distention of the gall bladder or the biliary duct on the movements of the stomach, small intestine and proximal colon were investigated in the dog anesthetized with pentobarbital sodium or in the spinal dog. The distention of the gall bladder with the pressure of 50 to 160 mmHg exerted an inhibitory effect on the movements of the stomach and small intestine and the excitatory or the inhibitory response on the colonic movements. In dogs whose spinal cord was transected between the 2nd and 3rd thoracic segments the inhibitory response was also obtained. In most cases, after bilateral sectioning of the thoracic splanchnic nerves the inhibitory response was not completely abolished, After the 1st lumbar through the 5th lumbar splanchnic nerves were bilaterally sectioned in addition, the inhibibitory response was completely abolished. After sectioning of the vagus nerves the excitatory response of the colonic movements was replaced by the inhibitory one. After severing the 4th thoracic through the 13th thoracic posterior roots the inhibitory response was also completely abolished. The afferent pathways responsible for the inhibitory reflex on the movements of the stomach and small intestine elicited by the distention of the gall bladder are the thoracic and the lumbar splanchnic nerves and the posterior roots of the 4th thoracic to the 13th thoracic segment, while the efferent inhibitory pathways are the thoracic and lumbar splanchnic nerves. The distention of the biliary ducts caused an excitatory or inhibitory effect on the gastric movements, while it always produced the inhibitory effect of the small intestine. After the sectioning of both vagi the excitatory effect on the stomach was reversed to the inhibitory one.

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