A PECULIAR DISCOLORATION OF THE SKIN

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Abstract
A limited number of drugs and chemicals are known to produce a fixed discoloration when applied to the surface of the skin. Olson1has carefully summarized our present knowledge of the localized argyrias. Pusey2describes an interesting pigmentation resulting from a solution of the sulphate of iron used in dressing dermatitis. Tattooing is, of course, familiar. The pigmentation resulting from the application of heat and irritating chemicals, such as mustard, cantharides and croton oil, are secondary to inflammatory changes and can usually be readily traced to the offending agent. I have not been able to find any reference in the literature to persistent discoloration resulting from the use of mercurial cosmetics. Recently, we have had the opportunity to observe two patients with such a pigmentation, resulting apparently from mercurial salts in a face cream. REPORT OF CASES Case 1. —Miss C. A., aged 45, a schoolteacher, who was

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