Aspartate Mutations in Presenilin and γ‐Secretase Inhibitors Both Impair Notch1 Proteolysis and Nuclear Translocation with Relative Preservation of Notch1 Signaling
Open Access
- 1 August 2000
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 75 (2) , 583-593
- https://doi.org/10.1046/j.1471-4159.2000.0750583.x
Abstract
It has been hypothesized that a presenilin 1 (PS1)-related enzymatic activity is responsible for proteolytic cleavage of the C-terminal intracellular protein of Notch1, in addition to its role in β-a...Keywords
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