THYRO-PITUITARY RELATIONSHIPS IN CHILDREN WITH CRETINISM AND HYPOTHYROIDISM*†

Abstract
Serum levels of thyrotropin in a group of euthyroid and hypothyroid infants and children before and after therapy with thyroid hormone are reported. Absence of thyrotropic activity in severe hypothyroidism and its presence after thyroid therapy were demonstrated and the significance of this observation discussed. Before attempting any final interpretation of the functional state of the pituitary in hypothyroid states, it is important to measure the level of thyrotropic activity in the serum.