Mapping of a novel gene for familial hypertrophic cardiomyopathy to chromosome 11
- 1 July 1993
- journal article
- Published by Springer Nature in Nature Genetics
- Vol. 4 (3) , 311-313
- https://doi.org/10.1038/ng0793-311
Abstract
Familial hypertrophic cardiomyopathy (FHC) is a cardiac disorder transmitted as an autosomal dominant trait. FHC has been shown to be genetically heterogeneous with less than 50% of published pedigrees being associated with mutations in the beta myosin heavy chain (beta-MHC) gene on chromosome 14q11-q12. A second locus has recently been reported on chromosome 1. We examined the segregation of microsatellite markers in a French pedigree for which the disease is not linked to beta-MHC gene. We found significant linkage of the disease locus to several (CA)n repeats located on chromosome 11 (lod scores between +3.3 and +4.98). The data suggest the localization of the novel FHC gene in a region spanning 17 centiMorgans.Keywords
This publication has 19 references indexed in Scilit:
- A disease locus for familial hypertrophic cardiomyopathy maps to chromosome 1q3Nature Genetics, 1993
- Detection of a new mutation in the beta-myosin heavy chain gene in an individual with hypertrophic cardiomyopathy.Journal of Clinical Investigation, 1992
- Novel missense mutation in cardiac β myosin heavy chain gene found in a japanese patient with hypertrophic cardiomyopathyBiochemical and Biophysical Research Communications, 1992
- A Comprehensive Genetic Linkage Map of the Human GenomeScience, 1992
- A second-generation linkage map of the human genomeNature, 1992
- A molecular basis for familial hypertrophic cardiomyopathy: A β cardiac myosin heavy chain gene missense mutationPublished by Elsevier ,1990
- Familial hypertrophic cardiomyopathy is a genetically heterogeneous disease.Journal of Clinical Investigation, 1990
- A molecular basis for familial hypertrophic cardiomyopathy: An αβ cardiac myosin heavy chain hybrid geneCell, 1990
- Mapping a Gene for Familial Hypertrophic Cardiomyopathy to Chromosome 14q1New England Journal of Medicine, 1989
- Patterns of inheritance in hypertrophic cardiomyopathy: Assessment by m-mode and two-dimensional echocardiographyThe American Journal of Cardiology, 1984